PGT Cycle Outcome Estimator

Enter your age and AMH to see a step-by-step estimate of your likely IVF and PGT-A cycle outcomes — from eggs collected through to euploid blastocysts available for transfer.

First cycle estimate · Based on SART national data

Your Profile

Age (years)

AMH (pmol/L) If unknown, leave blank for age-based estimate only

Sperm source

Insemination method

I have a specific genetic indication for PGT PGT-M (monogenic / single gene) or PGT-SR (structural rearrangement) — adds a genetic filter step to the funnel

PGT indication

Estimated Cycle Outcomes

Data Sources & Evidence Base

Oocyte yield Fanton et al. 2023 (Fertil Steril) — SART CORS 2014–2019, n=402,411 retrieval cycles. Strong positive linear correlation between AMH, age, and oocytes retrieved. AMH and age together predict oocyte yield; age alone dominates euploidy.

Blastocyst arrest Russo et al. 2025 (Aging) — 25,974 embryos from 1,928 cohorts. Developmental arrest rate increases with age: 33% (<35), 38% (35–37), 40% (38–40), 44% (41–42), 44%+ (>42). Arrest correlated with meiotic aneuploidy.

Euploidy rate PMC 2022 (Reprod Sci) & ART Calculator (Polyzos et al. 2019, Front Endocrinol) — Age is the sole significant predictor of euploidy rate (p<0.0001). AMH and oocyte number do not independently affect euploidy per biopsied blastocyst. ART Calculator validated in 1,547 ICSI/PGT-A cycles (r=0.91).

Euploid LBR SART CORS 2014 (Fertil Steril 2021) — Live birth rate from euploid blastocyst FET is ~60–65% in published SART data and does not vary significantly with infertility diagnosis or age once embryo is confirmed euploid. A conservative 50% figure is used here to account for real-world variation, patient age effects on implantation, and uterine factors not captured in population data. Estimates reflect a single euploid blastocyst SET.

Fertilisation SART CORS national data & clinical consensus — MII rate ~78–80%; ICSI fertilisation (2PN) rate ~75–80% of MII; conventional IVF ~65–75% of MII. Surgical sperm associated with lower fertilisation and blastocyst rates (ART Calculator, Polyzos 2019).

PGT-M genetics Mendelian inheritance — AR: 25% affected, 75% unaffected (carrier + non-carrier). AD: 50% affected, 50% unaffected. XLR: all female embryos unaffected; 50% of male embryos affected — effectively ~75% suitable for transfer. Rates are theoretical Mendelian probabilities applied to euploid blastocyst cohort.

PGT-SR rates Zhou et al. 2024 (BMC Pregnancy & Childbirth) — 4-year real-world retrospective cohort, 1,034 PGT-SR cycles, 4,129 biopsied blastocysts. Euploidy rates: reciprocal translocation 30.1%, Robertsonian translocation 46.1%, inversion 57.3%. These real-world figures are more conservative than theoretical meiotic segregation models, reflecting additional de novo aneuploidies on non-translocation chromosomes. Rates vary significantly by specific translocation and breakpoints.

Important: These estimates are based on national population-level data and are provided to help you understand the typical IVF and PGT journey. Individual outcomes vary considerably. This calculator is intended for patients naive to IVF (first stimulation cycle) with their own eggs. Genetic filter rates for PGT-M reflect Mendelian probabilities; PGT-SR rates are population averages and vary significantly by the specific translocation, breakpoint, and chromosome segments involved. It does not account for embryo morphology, sperm DNA fragmentation, uterine factors, or prior IVF response. All estimates should be discussed with your specialist and genetic counsellor. This tool does not constitute medical advice.